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We conducted a birth dating study of Rathke's pouch derivatives to determine whether the location of specialized cells at birth is correlated with the timing of cell cycle exit.
We find that all of the anterior lobe cell types initiate differentiation concurrently with a peak between e11.5 and e13.5.
Unlike the neural ectoderm, which has an inside out ordering of cell types based on age, the anterior pituitary appears to have its earliest born cells located farthest from the lumen.
Because gonadotropes occupy the most rostral locations, they should be specified before somatotropes that occupy the more caudal and lateral locations.
The development of the mouse pituitary gland from the oral ectoderm is similar to the neural tube in that the progenitors actively divide around the lumen of Rathke’s pouch, the precursor of the pituitary gland (Ikeda and Yoshimoto 1991; Ward ) positive, CYCLIN E positive transitional stage at the boundary between the lumenal area and the forming anterior lobe (Bilodeau et al., 2009).
Neural tube cells that have exited the cell cycle are truly post-mitotic; they do not re-enter the cell cycle.
Neural progenitors actively divide around the lumen of the neural tube, then exit the cell cycle and migrate towards the periphery where they differentiate into specialized cell types.
In the neural tube, the earliest born neurons are located in the ventricular zone, while the later born neurons are located in the superficial marginal zone (Luskin and Shatz, 1985).
During late mouse gestation and the post-natal period, anterior lobe progenitors re-enter the cell cycle and expand the populations of specialized, hormone-producing cells.
We conducted a birth dating study of Rathke’s pouch derivatives to determine whether the location of specialized cells at birth is correlated with the timing of cell cycle exit.